S R Wayne Chen Selected Research

Polymorphic catecholergic ventricular tachycardia

1/2021	Cardiac ryanodine receptor calcium release deficiency syndrome.
1/2021	Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis.
1/2021	Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death.
1/2018	Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.
3/2017	A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia.
1/2017	CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression.
11/2016	Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias.
11/2016	Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.
11/2016	Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.
10/2015	Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.

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S R Wayne Chen Research Topics

Disease

22	Cardiac Arrhythmias (Arrythmia) 01/2022 - 08/2004
15	Polymorphic catecholergic ventricular tachycardia 01/2021 - 07/2010
12	Sudden Death 01/2021 - 08/2002
12	Heart Failure 11/2016 - 03/2004
10	Ventricular Tachycardia 09/2015 - 08/2002
4	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2022 - 11/2005
3	Alzheimer Disease (Alzheimer's Disease) 11/2022 - 01/2020
3	Ventricular Fibrillation 01/2022 - 11/2007
2	Memory Disorders (Memory Loss) 11/2022 - 01/2020
2	Channelopathies 01/2022 - 03/2017
2	Paroxysmal ventricular fibrillation 01/2021 - 11/2007
2	Atrial Fibrillation 01/2021 - 11/2016
2	Bradycardia 09/2015 - 01/2014
2	Cardiomyopathies (Cardiomyopathy) 03/2015 - 03/2012
1	Intellectual Disability (Idiocy) 01/2022
1	Familial Sudden Death 01/2022
1	Cardiotoxicity 12/2018
1	Atherosclerosis 01/2017
1	Heart Diseases (Heart Disease) 11/2016
1	Long QT Syndrome 10/2015
1	Hypotension (Low Blood Pressure) 09/2015
1	Cardiomegaly (Heart Hypertrophy) 07/2014
1	Hypertrophy 07/2014
1	Tachycardia (Tachyarrhythmias) 10/2013
1	Atrioventricular Block 01/2013
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 03/2012
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 03/2012
1	Syncope (Fainting) 07/2010
1	Malignant Hyperthermia 07/2008
1	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 06/2008
1	Bidirectional tachycardia 11/2007
1	Myocardial Infarction 01/2006

Drug/Important Bio-Agent (IBA)

48	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 11/2022 - 08/2002
9	Carvedilol (Coreg)FDA LinkGeneric 12/2018 - 07/2011
7	Phenobarbital (Luminal)FDA Link 12/2016 - 08/2004
5	CalciumIBA 01/2022 - 06/2008
5	Amino Acids FDA Link 11/2016 - 03/2004
4	tacrolimus binding protein 1BIBA 07/2010 - 03/2004
2	Metoprolol (Toprol-XL)FDA LinkGeneric 01/2022 - 07/2011
2	Amyloid (Amyloid Fibrils)IBA 11/2021 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2012
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 11/2019 - 10/2015
2	Caffeine (No Doz)FDA LinkGeneric 11/2016 - 09/2008
2	Pharmaceutical PreparationsIBA 01/2016 - 11/2013
2	Adrenergic Agents (Adrenergic Drugs)IBA 07/2010 - 05/2006
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 04/2005 - 03/2004
1	Flecainide (Tambocor)FDA LinkGeneric 01/2022
1	CatecholaminesIBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	Ouabain (G Strophanthin)IBA 12/2018
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	ElementsIBA 01/2017
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2017
1	LDL Receptors (LDL Receptor)IBA 01/2017
1	SterolsIBA 01/2017
1	Nebivolol FDA Link 11/2016
1	CalsequestrinIBA 07/2014
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2013
1	phospholambanIBA 08/2013
1	Bisoprolol (Concor)FDA LinkGeneric 07/2011
1	Carrier Proteins (Binding Protein)IBA 07/2010
1	Tacrolimus Binding Proteins (FKBP)IBA 08/2007
1	RyanodineIBA 06/2007
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2006

Therapy/Procedure

1	General Anesthesia 07/2008